Establishing functional lentiviral vector production in a stirred bioreactor for CAR-T cell therapy

As gene delivery tools, lentiviral vectors (LV) have broad applications in chimeric antigen receptor therapy (CAR-T). Large-scale production of functional LV is limited by the adherent, serum-dependent nature of HEK293T cells used in the manufacturing. HEK293T adherent cells were adapted to suspensi...

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Detalles Bibliográficos
Autores principales: Tang, Qu-Lai, Gu, Li-Xing, Xu, Yao, Liao, Xing-Hua, Zhou, Yong, Zhang, Tong-Cun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806440/
https://www.ncbi.nlm.nih.gov/pubmed/34047682
http://dx.doi.org/10.1080/21655979.2021.1931644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8806440/
https://www.ncbi.nlm.nih.gov/pubmed/34047682
http://dx.doi.org/10.1080/21655979.2021.1931644

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