Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease

The loss of transient receptor potential mucolipin 1 (TRPML1), an endosomal and lysosomal Ca(2+)-releasing channel, has been implicated in neurodegenerative disorders. Mounting evidence have shown that TRPML1 could clear intraneuronal amyloid-β (Aβ), which triggers a hypothesis that TRPML1 activatio...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Fang, Yu, Cheng, Xuan, Lian, Yajun, Xu, Hongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807035/
https://www.ncbi.nlm.nih.gov/pubmed/35116093
http://dx.doi.org/10.1155/2022/8096009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807035/
https://www.ncbi.nlm.nih.gov/pubmed/35116093
http://dx.doi.org/10.1155/2022/8096009

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