Neutrophil depletion enhanced the Clostridium novyi-NT therapy in mouse and rabbit tumor models

BACKGROUND: Hypoxia is a prominent feature of solid tumors and can function as fertile environment for oncolytic anaerobic bacteria such as Clostridium novyi-NT (C. novyi-NT) where it can induce tumor destruction in mice and patients. However, two major obstacles have limited its use, namely the hos...

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Detalles Bibliográficos
Autores principales: Staedtke, Verena, Gray-Bethke, Tyler, Liu, Guanshu, Liapi, Eleni, Riggins, Gregory J, Bai, Ren-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807082/
https://www.ncbi.nlm.nih.gov/pubmed/35118381
http://dx.doi.org/10.1093/noajnl/vdab184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807082/
https://www.ncbi.nlm.nih.gov/pubmed/35118381
http://dx.doi.org/10.1093/noajnl/vdab184

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