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Neutrophil depletion enhanced the Clostridium novyi-NT therapy in mouse and rabbit tumor models
BACKGROUND: Hypoxia is a prominent feature of solid tumors and can function as fertile environment for oncolytic anaerobic bacteria such as Clostridium novyi-NT (C. novyi-NT) where it can induce tumor destruction in mice and patients. However, two major obstacles have limited its use, namely the hos...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807082/ https://www.ncbi.nlm.nih.gov/pubmed/35118381 http://dx.doi.org/10.1093/noajnl/vdab184 |