Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence

Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1‐associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying mechanism is unknown. We show that combined BAP1 deficiency and SF3B1 h...

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Detalles Bibliográficos
Autores principales: Yu, Le, Zhou, Dan, Zhang, Guiming, Ren, Zhonglu, Luo, Xin, Liu, Peng, Plouffe, Steven W., Meng, Zhipeng, Moroishi, Toshiro, Li, Yilei, Zhang, Yiyue, Brown, Joan Heller, Liu, Shuwen, Guan, Kun‐Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807356/
https://www.ncbi.nlm.nih.gov/pubmed/34706158
http://dx.doi.org/10.1002/1878-0261.13128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807356/
https://www.ncbi.nlm.nih.gov/pubmed/34706158
http://dx.doi.org/10.1002/1878-0261.13128

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