Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy mainly occurring at an advanced age with no single major genetic driver. Transgenic expression of TCL1 in B cells leads after a long latency to a CLL-like disease in aged Eµ-TCL1 mice suggesting that TCL1 overexpression is not sufficient for...

Descripción completa

Detalles Bibliográficos
Autores principales: Öztürk, Selcen, Paul, Yashna, Afzal, Saira, Gil-Farina, Irene, Jauch, Anna, Bruch, Peter-Martin, Kalter, Verena, Hanna, Bola, Arseni, Lavinia, Roessner, Philipp M., Schmidt, Manfred, Stilgenbauer, Stephan, Dietrich, Sascha, Lichter, Peter, Zapatka, Marc, Seiffert, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807396/
https://www.ncbi.nlm.nih.gov/pubmed/34417556
http://dx.doi.org/10.1038/s41375-021-01381-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807396/
https://www.ncbi.nlm.nih.gov/pubmed/34417556
http://dx.doi.org/10.1038/s41375-021-01381-4

Ejemplares similares