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Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy mainly occurring at an advanced age with no single major genetic driver. Transgenic expression of TCL1 in B cells leads after a long latency to a CLL-like disease in aged Eµ-TCL1 mice suggesting that TCL1 overexpression is not sufficient for...

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Detalles Bibliográficos
Autores principales:	Öztürk, Selcen, Paul, Yashna, Afzal, Saira, Gil-Farina, Irene, Jauch, Anna, Bruch, Peter-Martin, Kalter, Verena, Hanna, Bola, Arseni, Lavinia, Roessner, Philipp M., Schmidt, Manfred, Stilgenbauer, Stephan, Dietrich, Sascha, Lichter, Peter, Zapatka, Marc, Seiffert, Martina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807396/ https://www.ncbi.nlm.nih.gov/pubmed/34417556 http://dx.doi.org/10.1038/s41375-021-01381-4

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