A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis
Pulmonary toxicity is the most well-known severe complication related to both methotrexate and nitrofurantoin, which can present as acute, subacute, and chronic. Rheumatoid arthritis is also known to cause pulmonary disease if left untreated. In this report, we present a unique case of a 94-year-old...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807452/ https://www.ncbi.nlm.nih.gov/pubmed/35145797 http://dx.doi.org/10.7759/cureus.20892 |
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author | Kochhar, Smriti Bommu, Veera Jayasree Latha Kocur, Mariusz Shah, Viraj Cheriyath, Pramil Lake, Thomas |
author_facet | Kochhar, Smriti Bommu, Veera Jayasree Latha Kocur, Mariusz Shah, Viraj Cheriyath, Pramil Lake, Thomas |
author_sort | Kochhar, Smriti |
collection | PubMed |
description | Pulmonary toxicity is the most well-known severe complication related to both methotrexate and nitrofurantoin, which can present as acute, subacute, and chronic. Rheumatoid arthritis is also known to cause pulmonary disease if left untreated. In this report, we present a unique case of a 94-year-old female being treated with methotrexate for several years and then treated with nitrofurantoin in the setting of rheumatoid arthritis and chronic urinary tract infections, resulting in irreversible pulmonary fibrosis, which can further cause more susceptibility to infections and pneumonia. Drug-drug interactions are common in polypharmacy and a patient's history should be analyzed thoroughly before prescribing any new medication that can cause more harm to the patient than good. |
format | Online Article Text |
id | pubmed-8807452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-88074522022-02-09 A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis Kochhar, Smriti Bommu, Veera Jayasree Latha Kocur, Mariusz Shah, Viraj Cheriyath, Pramil Lake, Thomas Cureus Internal Medicine Pulmonary toxicity is the most well-known severe complication related to both methotrexate and nitrofurantoin, which can present as acute, subacute, and chronic. Rheumatoid arthritis is also known to cause pulmonary disease if left untreated. In this report, we present a unique case of a 94-year-old female being treated with methotrexate for several years and then treated with nitrofurantoin in the setting of rheumatoid arthritis and chronic urinary tract infections, resulting in irreversible pulmonary fibrosis, which can further cause more susceptibility to infections and pneumonia. Drug-drug interactions are common in polypharmacy and a patient's history should be analyzed thoroughly before prescribing any new medication that can cause more harm to the patient than good. Cureus 2022-01-03 /pmc/articles/PMC8807452/ /pubmed/35145797 http://dx.doi.org/10.7759/cureus.20892 Text en Copyright © 2022, Kochhar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Kochhar, Smriti Bommu, Veera Jayasree Latha Kocur, Mariusz Shah, Viraj Cheriyath, Pramil Lake, Thomas A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis |
title | A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis |
title_full | A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis |
title_fullStr | A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis |
title_full_unstemmed | A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis |
title_short | A Unique Interaction of Methotrexate and Nitrofurantoin Resulting in Irreversible Pulmonary Fibrosis |
title_sort | unique interaction of methotrexate and nitrofurantoin resulting in irreversible pulmonary fibrosis |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807452/ https://www.ncbi.nlm.nih.gov/pubmed/35145797 http://dx.doi.org/10.7759/cureus.20892 |
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