A Systematic Review on PD-1 Blockade and PD-1 Gene-Editing of CAR-T Cells for Glioma Therapy: From Deciphering to Personalized Medicine

BACKGROUND: Programmed cell death protein 1 (PD-1) can attenuate chimeric antigen receptor-T (CAR-T) cell-mediated anti-tumoral immune responses. In this regard, co-administration of anti-PD-1 with CAR-T cells and PD-1 gene-editing of CAR-T cells have been suggested to disrupt this inhibitory axis....

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Detalles Bibliográficos
Autores principales: Abdoli Shadbad, Mahdi, Hemmat, Nima, Khaze Shahgoli, Vahid, Derakhshani, Afshin, Baradaran, Farzad, Brunetti, Oronzo, Fasano, Rossella, Bernardini, Renato, Silvestris, Nicola, Baradaran, Behzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807490/
https://www.ncbi.nlm.nih.gov/pubmed/35126356
http://dx.doi.org/10.3389/fimmu.2021.788211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807490/
https://www.ncbi.nlm.nih.gov/pubmed/35126356
http://dx.doi.org/10.3389/fimmu.2021.788211

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