Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine

Pregnancy is accompanied by significant physiological changes that might affect the in vivo drug disposition. Olanzapine is prescribed to pregnant women with schizophrenia, while its pharmacokinetics during pregnancy remains unclear. This study aimed to develop a physiologically based pharmacokineti...

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Detalles Bibliográficos
Autores principales: Zheng, Liang, Yang, Hongyi, Dallmann, André, Jiang, Xuehua, Wang, Ling, Hu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807508/
https://www.ncbi.nlm.nih.gov/pubmed/35126130
http://dx.doi.org/10.3389/fphar.2021.793346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807508/
https://www.ncbi.nlm.nih.gov/pubmed/35126130
http://dx.doi.org/10.3389/fphar.2021.793346

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