Cargando…
The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease
Recent reports indicate that Parkinson's disease (PD) involves specific functional abnormalities in residual neurons – decreased vesicular sequestration of cytoplasmic catecholamines via the vesicular monoamine transporter (VMAT) and decreased aldehyde dehydrogenase (ALDH) activity. This double...
Autores principales: | Landau, Regev, Halperin, Reut, Sullivan, Patti, Zibly, Zion, Leibowitz, Avshalom, Goldstein, David S., Sharabi, Yehonatan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807569/ https://www.ncbi.nlm.nih.gov/pubmed/34842277 http://dx.doi.org/10.1242/dmm.049082 |
Ejemplares similares
-
Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease
por: Khashab, Rawan, et al.
Publicado: (2023) -
Modeling the Progression of Cardiac Catecholamine Deficiency in Lewy Body Diseases
por: Goldstein, David S., et al.
Publicado: (2022) -
Melatonin Prevents T Lymphocyte Infiltration to the Kidneys of Hypertensive Rats, Induced by a High-Salt Diet, by Preventing the Expression of CXCR3 Ligand Chemokines
por: Bier, Ariel, et al.
Publicado: (2021) -
High-Fructose Diet Increases Renal ChREBPβ Expression, Leading to Intrarenal Fat Accumulation in a Rat Model with Metabolic Syndrome
por: Bier, Ariel, et al.
Publicado: (2022) -
Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
por: Pan-Montojo, Francisco, et al.
Publicado: (2010)