Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling

Desmoplastic small round cell tumor (DSRCT) is characterized by the t(11;22)(p13;q12) translocation, which fuses the transcriptional regulatory domain of EWSR1 with the DNA-binding domain of WT1, resulting in the oncogenic EWSR1-WT1 fusion protein. The paucity of DSRCT disease models has hampered pr...

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Detalles Bibliográficos
Autores principales: Smith, Roger S., Odintsov, Igor, Liu, Zebing, Lui, Allan Jo-Weng, Hayashi, Takuo, Vojnic, Morana, Suehara, Yoshiyuki, Delasos, Lukas, Mattar, Marissa S., Hmeljak, Julija, Ramirez, Hillary A., Shaw, Melissa, Bui, Gabrielle, Hartono, Alifiani B., Gladstone, Eric, Kunte, Siddharth, Magnan, Heather, Khodos, Inna, De Stanchina, Elisa, La Quaglia, Michael P., Yao, Jinjuan, Laé, Marick, Lee, Sean B., Spraggon, Lee, Pratilas, Christine A., Ladanyi, Marc, Somwar, Romel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807576/
https://www.ncbi.nlm.nih.gov/pubmed/34841430
http://dx.doi.org/10.1242/dmm.047621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807576/
https://www.ncbi.nlm.nih.gov/pubmed/34841430
http://dx.doi.org/10.1242/dmm.047621

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