Vangl2–environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension

Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene mutations but these are heterozygous, not homozygous...

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Detalles Bibliográficos
Autores principales: Nychyk, Oleksandr, Galea, Gabriel L., Molè, Matteo, Savery, Dawn, Greene, Nicholas D. E., Stanier, Philip, Copp, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807581/
https://www.ncbi.nlm.nih.gov/pubmed/34842271
http://dx.doi.org/10.1242/dmm.049194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807581/
https://www.ncbi.nlm.nih.gov/pubmed/34842271
http://dx.doi.org/10.1242/dmm.049194

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