Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Prolactin-releasing peptide (PrRP) is an endogenous neuropeptide involved in appetite regulation and energy homeostasis. PrRP binds with high affinity to G-protein coupled receptor 10 (GPR10) and with lesser activity towards the neuropeptide FF receptor type 2 (NPFF2R). The present study aimed to de...

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Detalles Bibliográficos
Autores principales: Alexopoulou, Flora, Bech, Esben Matzen, Pedersen, Søren Ljungberg, Thorbek, Ditte Dencker, Leurs, Ulrike, Rudkjær, Lise Christine Biehl, Fosgerau, Keld, Hansen, Henrik H., Vrang, Niels, Jelsing, Jacob, Elster, Lisbeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807614/
https://www.ncbi.nlm.nih.gov/pubmed/35105898
http://dx.doi.org/10.1038/s41598-022-05310-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807614/
https://www.ncbi.nlm.nih.gov/pubmed/35105898
http://dx.doi.org/10.1038/s41598-022-05310-y

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