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A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state

Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release...

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Detalles Bibliográficos
Autores principales: Liu, Zhiyuan, Le, Qiumin, Lv, Yanbo, Chen, Xi, Cui, Jian, Zhou, Yiming, Cheng, Deqin, Ma, Chaonan, Su, Xiujuan, Xiao, Lei, Yang, Ruyi, Zhang, Jiayi, Ma, Lan, Liu, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807621/
https://www.ncbi.nlm.nih.gov/pubmed/34848869
http://dx.doi.org/10.1038/s41422-021-00588-5