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Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection

Homologous recombination enables cells to overcome the threat of DNA double-strand breaks (DSBs), allowing for repair without the loss of genetic information. Central to the homologous recombination repair process is the de novo loading of cohesin around a DSB by its loader complex Scc2/4. Although...

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Detalles Bibliográficos
Autores principales: Scherzer, Martin, Giordano, Fosco, Ferran, Maria Solé, Ström, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807874/
https://www.ncbi.nlm.nih.gov/pubmed/35086935
http://dx.doi.org/10.26508/lsa.202101244