Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages

In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines. Robust expression levels, lack of genotoxicity, and their manageable immunogenicity...

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Detalles Bibliográficos
Autores principales: Moradian, Hanieh, Roch, Toralf, Anthofer, Larissa, Lendlein, Andreas, Gossen, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807976/
https://www.ncbi.nlm.nih.gov/pubmed/35141046
http://dx.doi.org/10.1016/j.omtn.2022.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807976/
https://www.ncbi.nlm.nih.gov/pubmed/35141046
http://dx.doi.org/10.1016/j.omtn.2022.01.004

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