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Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages
In vitro transcribed (IVT)-mRNA has been accepted as a promising therapeutic modality. Advances in facile and rapid production technologies make IVT-mRNA an appealing alternative to protein- or virus-based medicines. Robust expression levels, lack of genotoxicity, and their manageable immunogenicity...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807976/ https://www.ncbi.nlm.nih.gov/pubmed/35141046 http://dx.doi.org/10.1016/j.omtn.2022.01.004 |