TIM-3 shuttled by MV3 cells-secreted exosomes inhibits CD4(+) T cell immune function and induces macrophage M2 polarization to promote the growth and metastasis of melanoma cells

This study is sought to determine the physiological mechanisms by which exosomes-encapsulated TIM-3 derived from melanoma cells might mediate CD4(+) T cell immune function and macrophage M2 polarization in melanoma. Initially, exosomes were isolated from the human skin-derived melanoma cell line MV3...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xinghui, Liu, Yu, Yang, Li, Jiang, Yannan, Qian, Qihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808081/
https://www.ncbi.nlm.nih.gov/pubmed/35093790
http://dx.doi.org/10.1016/j.tranon.2021.101334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808081/
https://www.ncbi.nlm.nih.gov/pubmed/35093790
http://dx.doi.org/10.1016/j.tranon.2021.101334

Ejemplares similares