The aqueous humor proteome is intrinsically disordered
• Our study demonstrated that intrinsic disorder is abundant in the aqueous humor. • The 749 aqueous proteins analyzed were enriched with disorder-promoting residues. • 208 aqueous humor proteins were predicted to be highly intrinsically disordered. • Misregulation of IDPs may promote pathology in t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808082/ https://www.ncbi.nlm.nih.gov/pubmed/35128080 http://dx.doi.org/10.1016/j.bbrep.2022.101202 |
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author | Djulbegovic, Mak Uversky, Vladimir N. |
author_facet | Djulbegovic, Mak Uversky, Vladimir N. |
author_sort | Djulbegovic, Mak |
collection | PubMed |
description | • Our study demonstrated that intrinsic disorder is abundant in the aqueous humor. • The 749 aqueous proteins analyzed were enriched with disorder-promoting residues. • 208 aqueous humor proteins were predicted to be highly intrinsically disordered. • Misregulation of IDPs may promote pathology in the aqueous humor. • IDPs in aqueous humor may serve as future targets for novel therapeutics. |
format | Online Article Text |
id | pubmed-8808082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88080822022-02-04 The aqueous humor proteome is intrinsically disordered Djulbegovic, Mak Uversky, Vladimir N. Biochem Biophys Rep Research Article • Our study demonstrated that intrinsic disorder is abundant in the aqueous humor. • The 749 aqueous proteins analyzed were enriched with disorder-promoting residues. • 208 aqueous humor proteins were predicted to be highly intrinsically disordered. • Misregulation of IDPs may promote pathology in the aqueous humor. • IDPs in aqueous humor may serve as future targets for novel therapeutics. Elsevier 2022-01-28 /pmc/articles/PMC8808082/ /pubmed/35128080 http://dx.doi.org/10.1016/j.bbrep.2022.101202 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Djulbegovic, Mak Uversky, Vladimir N. The aqueous humor proteome is intrinsically disordered |
title | The aqueous humor proteome is intrinsically disordered |
title_full | The aqueous humor proteome is intrinsically disordered |
title_fullStr | The aqueous humor proteome is intrinsically disordered |
title_full_unstemmed | The aqueous humor proteome is intrinsically disordered |
title_short | The aqueous humor proteome is intrinsically disordered |
title_sort | aqueous humor proteome is intrinsically disordered |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808082/ https://www.ncbi.nlm.nih.gov/pubmed/35128080 http://dx.doi.org/10.1016/j.bbrep.2022.101202 |
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