The aqueous humor proteome is intrinsically disordered

• Our study demonstrated that intrinsic disorder is abundant in the aqueous humor. • The 749 aqueous proteins analyzed were enriched with disorder-promoting residues. • 208 aqueous humor proteins were predicted to be highly intrinsically disordered. • Misregulation of IDPs may promote pathology in t...

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Detalles Bibliográficos
Autores principales: Djulbegovic, Mak, Uversky, Vladimir N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808082/
https://www.ncbi.nlm.nih.gov/pubmed/35128080
http://dx.doi.org/10.1016/j.bbrep.2022.101202
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author Djulbegovic, Mak
Uversky, Vladimir N.
author_facet Djulbegovic, Mak
Uversky, Vladimir N.
author_sort Djulbegovic, Mak
collection PubMed
description • Our study demonstrated that intrinsic disorder is abundant in the aqueous humor. • The 749 aqueous proteins analyzed were enriched with disorder-promoting residues. • 208 aqueous humor proteins were predicted to be highly intrinsically disordered. • Misregulation of IDPs may promote pathology in the aqueous humor. • IDPs in aqueous humor may serve as future targets for novel therapeutics.
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spelling pubmed-88080822022-02-04 The aqueous humor proteome is intrinsically disordered Djulbegovic, Mak Uversky, Vladimir N. Biochem Biophys Rep Research Article • Our study demonstrated that intrinsic disorder is abundant in the aqueous humor. • The 749 aqueous proteins analyzed were enriched with disorder-promoting residues. • 208 aqueous humor proteins were predicted to be highly intrinsically disordered. • Misregulation of IDPs may promote pathology in the aqueous humor. • IDPs in aqueous humor may serve as future targets for novel therapeutics. Elsevier 2022-01-28 /pmc/articles/PMC8808082/ /pubmed/35128080 http://dx.doi.org/10.1016/j.bbrep.2022.101202 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Djulbegovic, Mak
Uversky, Vladimir N.
The aqueous humor proteome is intrinsically disordered
title The aqueous humor proteome is intrinsically disordered
title_full The aqueous humor proteome is intrinsically disordered
title_fullStr The aqueous humor proteome is intrinsically disordered
title_full_unstemmed The aqueous humor proteome is intrinsically disordered
title_short The aqueous humor proteome is intrinsically disordered
title_sort aqueous humor proteome is intrinsically disordered
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808082/
https://www.ncbi.nlm.nih.gov/pubmed/35128080
http://dx.doi.org/10.1016/j.bbrep.2022.101202
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