Cargando…
Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites
The malaria-causing parasite Plasmodium falciparum is responsible for over 200 million infections and 400,000 deaths per year. At multiple stages during its complex life cycle, P. falciparum expresses several essential proteins tethered to its surface by glycosylphosphatidylinositol (GPI) anchors, w...
Autores principales: | Frasse, Philip M., Miller, Justin J., Polino, Alexander J., Soleimani, Ebrahim, Zhu, Jian-She, Jakeman, David L., Jez, Joseph M., Goldberg, Daniel E., Odom John, Audrey R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808168/ https://www.ncbi.nlm.nih.gov/pubmed/34973333 http://dx.doi.org/10.1016/j.jbc.2021.101550 |
Ejemplares similares
-
Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites
por: Guggisberg, Ann M., et al.
Publicado: (2018) -
Non‐canonical metabolic pathways in the malaria parasite detected by isotope‐tracing metabolomics
por: Cobbold, Simon A, et al.
Publicado: (2021) -
Haloacid Dehalogenase Proteins: Novel Mediators of Metabolic
Plasticity in Plasmodium falciparum
por: Frasse, Philip M, et al.
Publicado: (2019) -
Direct Tests of Enzymatic Heme Degradation by the Malaria Parasite Plasmodium falciparum
por: Sigala, Paul A., et al.
Publicado: (2012) -
A mutant of phosphomannomutase1 retains full enzymatic activity, but is not activated by IMP: Possible implications for the disease PMM2-CDG
por: Citro, Valentina, et al.
Publicado: (2017)