Functional coding haplotypes and machine-learning feature elimination identifies predictors of Methotrexate Response in Rheumatoid Arthritis patients

BACKGROUND: Major challenges in large scale genetic association studies include not only the identification of causative single nucleotide polymorphisms (SNPs), but also accounting for SNP-SNP interactions. This study thus proposes a novel feature engineering approach integrating potentially functio...

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Detalles Bibliográficos
Autores principales: Lim, Ashley J.W., Lim, Lee Jin, Ooi, Brandon N.S., Koh, Ee Tzun, Tan, Justina Wei Lynn, Chong, Samuel S., Khor, Chiea Chuen, Tucker-Kellogg, Lisa, Leong, Khai Pang, Lee, Caroline G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808170/
https://www.ncbi.nlm.nih.gov/pubmed/35022146
http://dx.doi.org/10.1016/j.ebiom.2021.103800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808170/
https://www.ncbi.nlm.nih.gov/pubmed/35022146
http://dx.doi.org/10.1016/j.ebiom.2021.103800

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