Cryo-EM structure of mouse TRPML2 in lipid nanodiscs

In mammalians, transient receptor potential mucolipin ion channels (TRPMLs) exhibit variable permeability to cations such as Ca(2+), Fe(2+), Zn(2+), and Na(+) and can be activated by the phosphoinositide PI(3,5)P2 in the endolysosomal system. Loss or dysfunction of TRPMLs has been implicated in lyso...

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Detalles Bibliográficos
Autores principales: Song, Xiaojing, Li, Jian, Tian, Miao, Zhu, Huaiyi, Hu, Xiaohui, Zhang, Yuting, Cao, Yanru, Ye, Heyang, McCormick, Peter J., Zeng, Bo, Fu, Yang, Duan, Jingjing, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808176/
https://www.ncbi.nlm.nih.gov/pubmed/34915027
http://dx.doi.org/10.1016/j.jbc.2021.101487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808176/
https://www.ncbi.nlm.nih.gov/pubmed/34915027
http://dx.doi.org/10.1016/j.jbc.2021.101487

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