Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation

Therapeutic antibody development requires discovery of an antibody molecule with desired specificities and drug-like properties. For toxicological studies, a therapeutic antibody must bind the ortholog antigen with a similar affinity to the human target to enable relevant dosing regimens, and antibo...

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Detalles Bibliográficos
Autores principales: Kielczewska, Agnieszka, D'Angelo, Igor, Amador, Maria Sheena, Wang, Tina, Sudom, Athena, Min, Xiaoshan, Rathanaswami, Palaniswami, Pigott, Craig, Foltz, Ian N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808179/
https://www.ncbi.nlm.nih.gov/pubmed/34973336
http://dx.doi.org/10.1016/j.jbc.2021.101533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808179/
https://www.ncbi.nlm.nih.gov/pubmed/34973336
http://dx.doi.org/10.1016/j.jbc.2021.101533

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