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Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation
Therapeutic antibody development requires discovery of an antibody molecule with desired specificities and drug-like properties. For toxicological studies, a therapeutic antibody must bind the ortholog antigen with a similar affinity to the human target to enable relevant dosing regimens, and antibo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808179/ https://www.ncbi.nlm.nih.gov/pubmed/34973336 http://dx.doi.org/10.1016/j.jbc.2021.101533 |