Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic

The mitochondrial solute carrier family 8 sodium/calcium/lithium exchanger, member B1 (NCLX) is an important mediator of calcium extrusion from mitochondria. In this study, we tested the hypothesis that physiological expression levels of NCLX are essential for maintaining neuronal resilience in the...

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Detalles Bibliográficos
Autores principales: Hagenston, Anna M., Yan, Jing, Bas-Orth, Carlos, Tan, Yanwei, Sekler, Israel, Bading, Hilmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808183/
https://www.ncbi.nlm.nih.gov/pubmed/34942149
http://dx.doi.org/10.1016/j.jbc.2021.101508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808183/
https://www.ncbi.nlm.nih.gov/pubmed/34942149
http://dx.doi.org/10.1016/j.jbc.2021.101508

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