Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

Coagulation cofactors profoundly regulate hemostasis and are appealing targets for anticoagulants. However, targeting such proteins has been challenging because they lack an active site. To address this, we isolate an RNA aptamer termed T18.3 that binds to both factor V (FV) and FVa with nanomolar a...

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Detalles Bibliográficos
Autores principales: Soule, Erin E., Yu, Haixiang, Olson, Lyra, Naqvi, Ibtehaj, Kumar, Shekhar, Krishnaswamy, Sriram, Sullenger, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808741/
https://www.ncbi.nlm.nih.gov/pubmed/35114109
http://dx.doi.org/10.1016/j.chembiol.2022.01.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808741/
https://www.ncbi.nlm.nih.gov/pubmed/35114109
http://dx.doi.org/10.1016/j.chembiol.2022.01.009

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