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First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence

SIGNIFICANCE: 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is currently used for image-guided glioma resection. Typically, this widefield imaging method highlights the bulk of high-grade gliomas, but it underperforms at the infiltrating edge where PpIX fluorescence is...

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Detalles Bibliográficos
Autores principales: Alfonso-García, Alba, Zhou, Xiangnan, Bec, Julien, Anbunesan, Silvia N., Fereidouni, Farzad, Jin, Lee-Way, Lee, Han S., Bloch, Orin, Marcu, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809358/
https://www.ncbi.nlm.nih.gov/pubmed/35112514
http://dx.doi.org/10.1117/1.JBO.27.2.020501