Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed a systems pharmacology model of intracellular signaling in peripheral neurons to identify novel drug targets for preven...

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Detalles Bibliográficos
Autores principales: Bloomingdale, Peter, Meregalli, Cristina, Pollard, Kevin, Canta, Annalisa, Chiorazzi, Alessia, Fumagalli, Giulia, Monza, Laura, Pozzi, Eleonora, Alberti, Paola, Ballarini, Elisa, Oggioni, Norberto, Carlson, Louise, Liu, Wensheng, Ghandili, Mehrnoosh, Ignatowski, Tracey A., Lee, Kelvin P., Moore, Michael J., Cavaletti, Guido, Mager, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809372/
https://www.ncbi.nlm.nih.gov/pubmed/35126148
http://dx.doi.org/10.3389/fphar.2021.817236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809372/
https://www.ncbi.nlm.nih.gov/pubmed/35126148
http://dx.doi.org/10.3389/fphar.2021.817236

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