Cargando…

Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed a systems pharmacology model of intracellular signaling in peripheral neurons to identify novel drug targets for preven...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bloomingdale, Peter, Meregalli, Cristina, Pollard, Kevin, Canta, Annalisa, Chiorazzi, Alessia, Fumagalli, Giulia, Monza, Laura, Pozzi, Eleonora, Alberti, Paola, Ballarini, Elisa, Oggioni, Norberto, Carlson, Louise, Liu, Wensheng, Ghandili, Mehrnoosh, Ignatowski, Tracey A., Lee, Kelvin P., Moore, Michael J., Cavaletti, Guido, Mager, Donald E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809372/ https://www.ncbi.nlm.nih.gov/pubmed/35126148 http://dx.doi.org/10.3389/fphar.2021.817236

Ejemplares similares

Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity
por: Meregalli, Cristina, et al.
Publicado: (2021)

High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in rats
por: Meregalli, Cristina, et al.
Publicado: (2018)

Reply to a Comment Paper on the Published Paper by Canta, A. et al: “Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity”—Antioxidants 2020, 9, 594
por: Canta, Annalisa, et al.
Publicado: (2020)

Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity
por: Canta, Annalisa, et al.
Publicado: (2020)

Paclitaxel, but Not Cisplatin, Affects Satellite Glial Cells in Dorsal Root Ganglia of Rats with Chemotherapy-Induced Peripheral Neurotoxicity
por: Pozzi, Eleonora, et al.
Publicado: (2023)

CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats
por: Meregalli, Cristina, et al.
Publicado: (2012)

Morpho-Functional Characterisation of the Rat Ventral Caudal Nerve in a Model of Axonal Peripheral Neuropathy
por: Pozzi, Eleonora, et al.
Publicado: (2023)

Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?
por: Ballarini, Elisa, et al.
Publicado: (2022)

Bortezomib-Induced Painful Peripheral Neuropathy: An Electrophysiological, Behavioral, Morphological and Mechanistic Study in the Mouse
por: Carozzi, Valentina A., et al.
Publicado: (2013)

Reversal of Bortezomib-Induced Neurotoxicity by Suvecaltamide, a Selective T-Type Ca-Channel Modulator, in Preclinical Models
por: Meregalli, Cristina, et al.
Publicado: (2021)

Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy
por: Pero, Maria Elena, et al.
Publicado: (2021)

Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy
por: Fumagalli, Giulia, et al.
Publicado: (2021)

Multimodal Comparison of Diabetic Neuropathy in Aged Streptozotocin-Treated Sprague–Dawley and Zucker Diabetic Fatty Rats
por: Canta, Annalisa, et al.
Publicado: (2022)

Inhibition of NHE1 transport activity and gene transcription in DRG neurons in oxaliplatin-induced painful peripheral neurotoxicity
por: Dionisi, Marianna, et al.
Publicado: (2023)

Addressing the Need of a Translational Approach in Peripheral Neuropathy Research: Morphology Meets Function
por: Monza, Laura, et al.
Publicado: (2021)

A mechanistic understanding of the relationship between skin innervation and chemotherapy-induced neuropathic pain
por: Meregalli, Cristina, et al.
Publicado: (2022)

Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification
por: Dionisi, Marianna, et al.
Publicado: (2020)

An Overview of Bortezomib-Induced Neurotoxicity
por: Meregalli, Cristina
Publicado: (2015)

Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect
por: Malacrida, A., et al.
Publicado: (2021)

Bortezomib Treatment Produces Nocifensive Behavior and Changes in the Expression of TRPV1, CGRP, and Substance P in the Rat DRG, Spinal Cord, and Sciatic Nerve
por: Quartu, M., et al.
Publicado: (2014)

Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: Phenotypic and genotypic insights
por: Marmiroli, Paola, et al.
Publicado: (2017)

Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin
por: Hucke, Anna, et al.
Publicado: (2023)

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain
por: Stockstill, Katherine, et al.
Publicado: (2018)

Ubiquitin Proteasome System and Microtubules Are Master Regulators of Central and Peripheral Nervous System Axon Degeneration
por: Cartelli, Daniele, et al.
Publicado: (2022)

GATA3-dependent epigenetic upregulation of CCL21 is involved in the development of neuropathic pain induced by bortezomib
por: Zheng, Yaochao, et al.
Publicado: (2019)

Inhibition of microRNA-155 Reduces Neuropathic Pain During Chemotherapeutic Bortezomib via Engagement of Neuroinflammation
por: Duan, Zongsheng, et al.
Publicado: (2020)

Pharmacodynamic Models of Differential Bortezomib Signaling Across Several Cell Lines of Multiple Myeloma
por: Ramakrishnan, Vidya, et al.
Publicado: (2018)

Authors’ Reply to Whitlock: Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence
por: Ignatowski, Tracey A., et al.
Publicado: (2014)

Bortezomib
por: Rajappa, Senthil
Publicado: (2010)

Progress on the Application of Bortezomib and Bortezomib-Based Nanoformulations
por: Liu, Jianhao, et al.
Publicado: (2021)

Mitochondrial Dysfunction in Chemotherapy-Induced Peripheral Neuropathy (CIPN)
por: Canta, Annalisa, et al.
Publicado: (2015)

Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain
por: Bechakra, Malik, et al.
Publicado: (2018)

Reduction of SIRT1 epigenetically upregulates NALP1 expression and contributes to neuropathic pain induced by chemotherapeutic drug bortezomib
por: Chen, Kun, et al.
Publicado: (2018)

Anti-tumor Efficacy Assessment of the Sigma Receptor Pan Modulator RC-106. A Promising Therapeutic Tool for Pancreatic Cancer
por: Tesei, Anna, et al.
Publicado: (2019)

The Actions and Mechanisms of P2X7R and p38 MAPK Activation in Mediating Bortezomib-Induced Neuropathic Pain
por: Guo, Yan, et al.
Publicado: (2020)

Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria
por: Alberti, Paola, et al.
Publicado: (2022)

Bortezomib in Kidney Transplantation
por: Raghavan, Rajeev, et al.
Publicado: (2010)

Making Connections: Mesenchymal Stem Cells Manifold Ways to Interact with Neurons
por: Tarasiuk, Olga, et al.
Publicado: (2022)

Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?
por: Cavaletti, Guido, et al.
Publicado: (2021)

Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance
por: Kraus, M, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_v5vij59ufqevvdqc5clqleo81e