Gating choreography and mechanism of the human proton-activated chloride channel ASOR

The proton-activated chloride channel ASOR (TMEM206/PAC) permeates anions across cellular membranes in response to acidification, thereby enhancing acid-induced cell death and regulating endocytosis. The molecular mechanisms of pH-dependent control are not understood, in part because structural info...

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Detalles Bibliográficos
Autores principales: Wang, Chongyuan, Polovitskaya, Maya M., Delgado, Bryce D., Jentsch, Thomas J., Long, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809534/
https://www.ncbi.nlm.nih.gov/pubmed/35108041
http://dx.doi.org/10.1126/sciadv.abm3942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809534/
https://www.ncbi.nlm.nih.gov/pubmed/35108041
http://dx.doi.org/10.1126/sciadv.abm3942

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