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A noncanonical chaperone interacts with drug efflux pumps during their assembly into bacterial outer membranes

Bacteria have membrane-spanning efflux pumps to secrete toxic compounds ranging from heavy metal ions to organic chemicals, including antibiotic drugs. The overall architecture of these efflux pumps is highly conserved: with an inner membrane energy-transducing subunit coupled via an adaptor protein...

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Detalles Bibliográficos
Autores principales: Stubenrauch, Christopher J., Bamert, Rebecca S., Wang, Jiawei, Lithgow, Trevor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809574/
https://www.ncbi.nlm.nih.gov/pubmed/35061668
http://dx.doi.org/10.1371/journal.pbio.3001523