Cargando…

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis

Dysregulation of calcium homeostasis has been hypothesized to play a role in Alzheimer’s disease (AD) pathogenesis. Increased calcium levels can impair axonal transport, disrupt synaptic transmission, and ultimately lead to cell death. Given the potential role of calcium dyshomeostasis in AD, there...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadleir, Katherine R., Popovic, Jelena, Khatri, Ammaarah, Vassar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809624/ https://www.ncbi.nlm.nih.gov/pubmed/35108319 http://dx.doi.org/10.1371/journal.pone.0263332

Ejemplares similares

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease
por: Sadleir, Katherine R., et al.
Publicado: (2018)

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
por: Sadleir, Katherine R., et al.
Publicado: (2021)

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
por: Sadleir, Katherine R, et al.
Publicado: (2015)

Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis
por: Maarouf, Chera L, et al.
Publicado: (2013)

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease
por: Sadleir, Katherine R., et al.
Publicado: (2016)

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
por: Chandra, Sidhanth, et al.
Publicado: (2023)

Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer’s disease
por: Sadleir, Katherine R., et al.
Publicado: (2023)

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mouse Model of Alzheimer’s Disease
por: Sadleir, Katherine R., et al.
Publicado: (2014)

Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model
por: Jović, Milena, et al.
Publicado: (2019)

Neuroprotective and Neuroregenerative Effects of Nimodipine in a Model System of Neuronal Differentiation and Neurite Outgrowth
por: Bork, Kaya, et al.
Publicado: (2015)

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
por: Shin, Soo Jung, et al.
Publicado: (2018)

Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models
por: Alia, Alia O., et al.
Publicado: (2022)

Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease
por: Paladugu, Leela, et al.
Publicado: (2021)

The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method
por: Dobrowolska Zakaria, Justyna A., et al.
Publicado: (2022)

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET
por: Oh, Se Jong, et al.
Publicado: (2018)

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
por: Cuddy, Leah K., et al.
Publicado: (2022)

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021)

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation
por: Eimer, William A, et al.
Publicado: (2013)

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
por: Andersen, Jens V., et al.
Publicado: (2021)

Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord
por: Chu, Tak-Ho, et al.
Publicado: (2017)

Modified amyloid variants in pathological subgroups of β‐amyloidosis
por: Gerth, Janina, et al.
Publicado: (2018)

Transferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain
por: Choi, Moonseok, et al.
Publicado: (2023)

The effects of STZ-induced diabetes on cognition and brain amyloid in 5XFAD mouse model of Alzheimer’s disease
por: Sonn, Katrin, et al.
Publicado: (2015)

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
por: Park, Sohui, et al.
Publicado: (2021)

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
por: Kandalepas, Patty C., et al.
Publicado: (2013)

Erratum to: The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
por: Kandalepas, Patty C., et al.
Publicado: (2013)

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine
por: Chiozzi, Paola, et al.
Publicado: (2019)

Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease
por: Wei, Zhen, et al.
Publicado: (2016)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease
por: Bugrova, Anna E., et al.
Publicado: (2021)

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model
por: Shin, Jisu, et al.
Publicado: (2021)

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
por: Farfara, Dorit, et al.
Publicado: (2023)

Antenatal Hypoxia Accelerates the Onset of Alzheimer’s Disease Pathology in 5xFAD Mouse Model
por: Shen, Guofang, et al.
Publicado: (2020)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
por: Sosna, Justyna, et al.
Publicado: (2018)

5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility
por: Yelleswarapu, Narayana Krishna, et al.
Publicado: (2022)

The novel estrogen receptor modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer’s disease
por: Quinn, Joseph F., et al.
Publicado: (2022)

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice
por: Kook, S-Y, et al.
Publicado: (2014)

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
por: Lee, Donghee, et al.
Publicado: (2023)

MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease
por: Jeong, Yu-on, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mo1sc5r9c6id2dvq49o508q8mi