Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1))

To verify whether Ang-(1-7) produces an antagonistic effect on Ang II-mediated atrial remodeling. Ang II–induced HL-1 cell model and a rat model of Ang II–induced atrial remodeling were constructed and intervened with Ang II Ang-(1-7), AngII +Ang-(1-7), Ang II+ c-Src specific inhibitor (SU6656), and...

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Detalles Bibliográficos
Autores principales: Lu, Li, Cao, Li, Liu, Yihao, Chen, Yunlin, Fan, Jinqi, Yin, Yuehui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809921/
https://www.ncbi.nlm.nih.gov/pubmed/34872449
http://dx.doi.org/10.1080/21655979.2021.1967035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8809921/
https://www.ncbi.nlm.nih.gov/pubmed/34872449
http://dx.doi.org/10.1080/21655979.2021.1967035

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