IL-13Rα2 humanized scFv-based CAR-T cells exhibit therapeutic activity against glioblastoma

Chimeric antigen receptor (CAR)-modified T cells have exhibited impressive anti-tumor effects in both B cell malignancies and some types of solid tumors. However, single-chain variable fragment (scFv) of a murine monoclonal antibody will induce immune responses, limit CAR-T cell persistence, and thu...

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Detalles Bibliográficos
Autores principales: Xu, Chang, Bai, Yue, An, Zhijing, Hu, Yi, Zhang, Can, Zhong, Xiaosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810302/
https://www.ncbi.nlm.nih.gov/pubmed/35141400
http://dx.doi.org/10.1016/j.omto.2022.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810302/
https://www.ncbi.nlm.nih.gov/pubmed/35141400
http://dx.doi.org/10.1016/j.omto.2022.01.002

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