Precise genome editing across kingdoms of life using retron-derived DNA

Exogenous DNA can be a template to precisely edit a cell’s genome. However, the delivery of in vitro-produced DNA to target cells can be inefficient, and low abundance of template DNA may underlie the low rate of precise editing. One potential tool to produce template DNA inside cells is a retron, a...

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Detalles Bibliográficos
Autores principales: Lopez, Santiago C., Crawford, Kate D., Lear, Sierra K., Bhattarai-Kline, Santi, Shipman, Seth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810715/
https://www.ncbi.nlm.nih.gov/pubmed/34949838
http://dx.doi.org/10.1038/s41589-021-00927-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810715/
https://www.ncbi.nlm.nih.gov/pubmed/34949838
http://dx.doi.org/10.1038/s41589-021-00927-y

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