Structure-based prediction of HDAC6 substrates validated by enzymatic assay reveals determinants of promiscuity and detects new potential substrates

Histone deacetylases play important biological roles well beyond the deacetylation of histone tails. In particular, HDAC6 is involved in multiple cellular processes such as apoptosis, cytoskeleton reorganization, and protein folding, affecting substrates such as ɑ-tubulin, Hsp90 and cortactin protei...

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Detalles Bibliográficos
Autores principales: Varga, Julia K., Diffley, Kelsey, Welker Leng, Katherine R., Fierke, Carol A., Schueler-Furman, Ora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810773/
https://www.ncbi.nlm.nih.gov/pubmed/35110592
http://dx.doi.org/10.1038/s41598-022-05681-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810773/
https://www.ncbi.nlm.nih.gov/pubmed/35110592
http://dx.doi.org/10.1038/s41598-022-05681-2

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