Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma

Von Hippel-Lindau (VHL) is an important tumor suppressor, and its inactivation is a hallmark of inherited VHL disease and most sporadic clear cell renal cell carcinoma (ccRCC). VHL protein (pVHL) with missense point mutations are unstable and degraded by the proteasome because of the disruption of e...

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Detalles Bibliográficos
Autores principales: Guo, Kai, Wei, Yinghua, Wang, Ze, Zhang, Xiaoli, Zhang, Xin, Liu, Xinxin, Wu, Wenyong, Wu, Zhengsheng, Zhang, Lingqiang, Cui, Chun-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810859/
https://www.ncbi.nlm.nih.gov/pubmed/35110537
http://dx.doi.org/10.1038/s41419-021-04135-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810859/
https://www.ncbi.nlm.nih.gov/pubmed/35110537
http://dx.doi.org/10.1038/s41419-021-04135-3

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