Cargando…

Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid

Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Nevertheless, as the most potent natural toxin, BoNT is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nowakowska, Maria B., Selby, Katja, Przykopanski, Adina, Krüger, Maren, Krez, Nadja, Dorner, Brigitte G., Dorner, Martin B., Jin, Rongsheng, Minton, Nigel P., Rummel, Andreas, Lindström, Miia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810926/ https://www.ncbi.nlm.nih.gov/pubmed/35110559 http://dx.doi.org/10.1038/s41598-022-05008-1

Ejemplares similares

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
por: Liu, Zheng, et al.
Publicado: (2023)

Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype
por: Kull, Skadi, et al.
Publicado: (2015)

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
por: Weisemann, Jasmin, et al.
Publicado: (2016)

Two-Component Signal Transduction System CBO0787/CBO0786 Represses Transcription from Botulinum Neurotoxin Promoters in Clostridium botulinum ATCC 3502
por: Zhang, Zhen, et al.
Publicado: (2013)

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test
por: Weisemann, Jasmin, et al.
Publicado: (2015)

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1
por: Lam, Kwok-ho, et al.
Publicado: (2018)

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding
por: Yao, Guorui, et al.
Publicado: (2017)

Conjugative Botulinum Neurotoxin-Encoding Plasmids in Clostridium botulinum
por: Marshall, Kristin M., et al.
Publicado: (2010)

Genomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut
por: Douillard, François P., et al.
Publicado: (2022)

Heat shock and prolonged heat stress attenuate neurotoxin and sporulation gene expression in group I Clostridium botulinum strain ATCC 3502
por: Selby, Katja, et al.
Publicado: (2017)

Selection and Development of Nontoxic Nonproteolytic Clostridium botulinum Surrogate Strains for Food Challenge Testing
por: Poortmans, Marijke, et al.
Publicado: (2022)

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature
por: Peck, Michael W., et al.
Publicado: (2017)

CRISPR-Cas9-Based Toolkit for Clostridium botulinum Group II Spore and Sporulation Research
por: Mertaoja, Anna, et al.
Publicado: (2021)

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments
por: von Berg, Laura, et al.
Publicado: (2019)

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission
por: Zanetti, Giulia, et al.
Publicado: (2017)

Posttranslational Regulation of Botulinum Neurotoxin Production in Clostridium botulinum Hall A-hyper
por: Inzalaco, Heather N’te, et al.
Publicado: (2021)

Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test
por: Worbs, Sylvia, et al.
Publicado: (2015)

Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody
por: Derman, Yağmur, et al.
Publicado: (2016)

Genome sequence of Clostridium sporogenes DSM 795(T), an amino acid-degrading, nontoxic surrogate of neurotoxin-producing Clostridium botulinum
por: Poehlein, Anja, et al.
Publicado: (2015)

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
por: von Berg, Laura, et al.
Publicado: (2019)

Regulatory Networks Controlling Neurotoxin Synthesis in Clostridium botulinum and Clostridium tetani
por: Popoff, Michel R., et al.
Publicado: (2022)

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
por: Stern, Daniel, et al.
Publicado: (2018)

Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain
por: Pellett, Sabine, et al.
Publicado: (2016)

Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples
por: Simon, Stéphanie, et al.
Publicado: (2015)

Pathogenicity and virulence of Clostridium botulinum
por: Rawson, Alexander M., et al.
Publicado: (2023)

On Botulinum Neurotoxin Variability
por: Montecucco, Cesare, et al.
Publicado: (2015)

Reoccurrence of botulinum neurotoxin subtype A3 inducing food-borne botulism, Slovakia, 2015
por: Mad’arová, Lucia, et al.
Publicado: (2017)

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)–K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
por: Sikorra, Stefan, et al.
Publicado: (2018)

Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type
por: Gonzalez-Escalona, Narjol, et al.
Publicado: (2014)

Recombinant Botulinum Neurotoxin Hc Subunit (BoNT Hc) and Catalytically Inactive Clostridium botulinum Holoproteins (ciBoNT HPs) as Vaccine Candidates for the Prevention of Botulism
por: Webb, Robert P., et al.
Publicado: (2017)

Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
por: Poulain, Bernard, et al.
Publicado: (2019)

Two-Component Systems Are Involved in the Regulation of Botulinum Neurotoxin Synthesis in Clostridium botulinum Type A Strain Hall
por: Connan, Chloé, et al.
Publicado: (2012)

Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system
Publicado: (1979)

Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum
por: Carter, Andrew T, et al.
Publicado: (2009)

Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
por: Carter, Andrew T., et al.
Publicado: (2015)

Endogenous CRISPR-Cas Systems in Group I Clostridium botulinum and Clostridium sporogenes Do Not Directly Target the Botulinum Neurotoxin Gene Cluster
por: Wentz, Travis G., et al.
Publicado: (2022)

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
por: Yao, Guorui, et al.
Publicado: (2016)

Sporulation Strategies and Potential Role of the Exosporium in Survival and Persistence of Clostridium botulinum
por: Portinha, Inês M., et al.
Publicado: (2022)

Zebrafish Sensitivity to Botulinum Neurotoxins
por: Chatla, Kamalakar, et al.
Publicado: (2016)

Use of Botulinum Neurotoxin in Ophthalmology
por: Başar, Emel, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_v1kd077u1v7vq616dor9r3uvut