Cargando…

β-III-spectrin N-terminus is required for high-affinity actin binding and SCA5 neurotoxicity

Recent structural studies of β-III-spectrin and related cytoskeletal proteins revealed N-terminal sequences that directly bind actin. These sequences are variable in structure, and immediately precede a conserved actin-binding domain composed of tandem calponin homology domains (CH1 and CH2). Here w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Denha, Sarah A., Atang, Alexandra E., Hays, Thomas S., Avery, Adam W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810934/ https://www.ncbi.nlm.nih.gov/pubmed/35110634 http://dx.doi.org/10.1038/s41598-022-05762-2

Ejemplares similares

Increased Actin Binding Is a Shared Molecular Consequence of Numerous SCA5 Mutations in β-III-Spectrin
por: Atang, Alexandra E., et al.
Publicado: (2023)

Increased actin binding is a shared molecular consequence of numerous spinocerebellar ataxia mutations in β-III-spectrin
por: Atang, Alexandra E., et al.
Publicado: (2023)

Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5
por: Guhathakurta, Piyali, et al.
Publicado: (2023)

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
por: Avery, Adam W., et al.
Publicado: (2017)

A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding
por: Avery, Adam W., et al.
Publicado: (2016)

Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin
por: Rebbeck, Robyn T., et al.
Publicado: (2020)

Binding sites of calmodulin and actin on the brain spectrin, calspectin
Publicado: (1983)

Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
por: Wang, Guiping, et al.
Publicado: (2019)

The Actin Binding Domain of βI-Spectrin Regulates the Morphological and Functional Dynamics of Dendritic Spines
por: Nestor, Michael W., et al.
Publicado: (2011)

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST
por: Perkins, Emma M., et al.
Publicado: (2016)

Beta spectrin bestows protein 4.1 sensitivity on spectrin-actin interactions
Publicado: (1987)

Erythrocyte adducin: a calmodulin-regulated actin-bundling protein that stimulates spectrin-actin binding
Publicado: (1987)

The utrophin actin-binding domain binds F-actin in two different modes: implications for the spectrin superfamily of proteins
por: Galkin, Vitold E., et al.
Publicado: (2002)

β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations
por: Clarkson, Yvonne L., et al.
Publicado: (2014)

The Actin/Spectrin Membrane-Associated Periodic Skeleton in Neurons
por: Unsain, Nicolas, et al.
Publicado: (2018)

Membrane domain organization of myelinated axons requires βII spectrin
por: Zhang, Chuansheng, et al.
Publicado: (2013)

Shape and volume changes in erythrocyte ghosts and spectrin-actin networks
Publicado: (1980)

Spectrin-dependent and -independent association of F-actin with the erythrocyte membrane
Publicado: (1980)

Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses
por: Sidenstein, Sven C., et al.
Publicado: (2016)

Cerebellar ataxias: β‐III spectrin's interactions suggest common pathogenic pathways
por: Perkins, Emma, et al.
Publicado: (2016)

Nodal β spectrins are required to maintain Na(+) channel clustering and axon integrity
por: Liu, Cheng-Hsin, et al.
Publicado: (2020)

Drosophila development requires spectrin network formation
Publicado: (1995)

Electron microscope study of reassociation of spectrin and actin with the human erythrocyte membrane
por: Tsukita, S, et al.
Publicado: (1981)

Regulation of actin-Spectrin cytoskeleton by ICA69 at the Drosophila neuromuscular junction
por: Mallik, Bhagaban, et al.
Publicado: (2017)

Recessive Mutations in SPTBN2 Implicate β-III Spectrin in Both Cognitive and Motor Development
por: Lise, Stefano, et al.
Publicado: (2012)

Functional characterization of protein 4.1 homolog in amphioxus: Defining a cryptic spectrin-actin-binding site
por: Wang, Lixia, et al.
Publicado: (2013)

The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin
por: Hajdu, Peter, et al.
Publicado: (2015)

αII-spectrin and βII-spectrin do not affect TGFβ1-induced myofibroblast differentiation
por: Piersma, Bram, et al.
Publicado: (2018)

The Mycobacteriophage Ms6 LysB N-Terminus Displays Peptidoglycan Binding Affinity
por: Gigante, Adriano M., et al.
Publicado: (2021)

Drosophila sosie functions with β(H)-Spectrin and actin organizers in cell migration, epithelial morphogenesis and cortical stability
por: Urwyler, Olivier, et al.
Publicado: (2012)

βH‐spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination
por: Krueger, Daniel, et al.
Publicado: (2020)

Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening
Publicado: (1995)

Nonerythrocyte spectrins: actin-membrane attachment proteins occurring in many cell types
Publicado: (1982)

Spectrin promotes the association of F-actin with the cytoplasmic surface of the human erythrocyte membrane
por: Fowler, VM, et al.
Publicado: (1981)

α-Adducin dissociates from F-actin and spectrin during platelet activation
por: Barkalow, Kurt L., et al.
Publicado: (2003)

The axonal actin-spectrin lattice acts as a tension buffering shock absorber
por: Dubey, Sushil, et al.
Publicado: (2020)

Actin‐spectrin scaffold supports open fenestrae in liver sinusoidal endothelial cells
por: Zapotoczny, Bartlomiej, et al.
Publicado: (2019)

Expanding the β-III Spectrin-Associated Phenotypes toward Non-Progressive Congenital Ataxias with Neurodegeneration
por: Sancho, Paula, et al.
Publicado: (2021)

Drosophila β Spectrin Functions Independently of α Spectrin to Polarize the Na,k Atpase in Epithelial Cells
por: Dubreuil, Ronald R., et al.
Publicado: (2000)

Axons break in animals lacking β-spectrin
por: Hammarlund, Marc, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_vmh44v8kc9b3c9c83jftv05gbc