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BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids
β-site APP-cleaving enzyme 2 (BACE2) is a homolog of BACE1, which is considered as the most promising therapeutic target for Alzheimer’s disease (AD). However, the expression and functional role of BACE2 in central nervous system (CNS) remain obscured. Previously, we identified several BACE2 rare va...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811022/ https://www.ncbi.nlm.nih.gov/pubmed/35110536 http://dx.doi.org/10.1038/s41420-022-00845-5 |