Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification

BACKGROUND: Extracellular acidification is a common feature of atherosclerotic lesions, and such an acidic microenvironment impedes ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux and promotes atherogenesis. However, the underlying mechanism is still unclear. Acid-sensing ion...

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Detalles Bibliográficos
Autores principales: Wang, Yuan-Mei, Tan, Mo-Ye, Zhang, Rong-Jie, Qiu, Ming-Yue, Fu, You-Sheng, Xie, Xue-Jiao, Gu, Hong-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811198/
https://www.ncbi.nlm.nih.gov/pubmed/35126174
http://dx.doi.org/10.3389/fphys.2021.777386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811198/
https://www.ncbi.nlm.nih.gov/pubmed/35126174
http://dx.doi.org/10.3389/fphys.2021.777386

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