Cargando…

Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway

Spinal cord injury (SCI) is a catastrophic event mainly involving neuronal apoptosis and axonal disruption, and it causes severe motor and sensory deficits. Due to the complicated pathological process of SCI, there is currently still a lack of effective treatment for SCI. Microglia, a type of immune...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Chengjun, Qin, Tian, Liu, Yudong, Wen, Haicheng, Zhao, Jinyun, Luo, Zixiang, Peng, Wei, Lu, Hongbin, Duan, Chunyue, Cao, Yong, Hu, Jianzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811263/ https://www.ncbi.nlm.nih.gov/pubmed/35127706 http://dx.doi.org/10.3389/fcell.2021.783017

Ejemplares similares

Bone Marrow Mesenchymal Stem Cell-Derived Exosome-Educated Macrophages Promote Functional Healing After Spinal Cord Injury
por: Li, Chengjun, et al.
Publicado: (2021)

Local delivery of EGFR(+)NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway
por: Qin, Tian, et al.
Publicado: (2023)

Hypoxia-Induced ZWINT Mediates Pancreatic Cancer Proliferation by Interacting With p53/p21
por: Chen, Peng, et al.
Publicado: (2021)

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Accelerate Functional Recovery After Spinal Cord Injury by Promoting the Phagocytosis of Macrophages to Clean Myelin Debris
por: Sheng, Xiaolong, et al.
Publicado: (2021)

Age‐associated expression of p21and p53 during human wound healing
por: Chia, Chee W., et al.
Publicado: (2021)

Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer
por: Shen, Aling, et al.
Publicado: (2022)

Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells
por: Peng, Wei, et al.
Publicado: (2021)

Cdk6: At the interface of Rb and p53
por: Nebenfuehr, Sofie, et al.
Publicado: (2018)

p63 and p53: Collaborative Partners or Dueling Rivals?
por: Woodstock, Dana L., et al.
Publicado: (2021)

Functional Versatility of the CDK Inhibitor p57(Kip2)
por: Creff, Justine, et al.
Publicado: (2020)

Progress report of experiment S151: $K^{-}p$ and $\bar{p}p$ x-rays
por: CERN. Geneva. Proton Synchrotron and Synchrocyclotron Committee
Publicado: (1976)

AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes
por: He, Pei, et al.
Publicado: (2020)

Mechanical overloading-induced miR-325-3p reduction promoted chondrocyte senescence and exacerbated facet joint degeneration
por: Zhao, Jinyun, et al.
Publicado: (2023)

The p53/p73 - p21(CIP1) tumor suppressor axis guards against chromosomal instability by restraining CDK1 in human cancer cells
por: Schmidt, Ann-Kathrin, et al.
Publicado: (2020)

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21
por: Colleoni, B, et al.
Publicado: (2017)

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway
por: Dinh, Tra Thi Huong, et al.
Publicado: (2021)

SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma
por: Hou, Yuchen, et al.
Publicado: (2019)

The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27
por: Rodriguez-Cupello, Carmen, et al.
Publicado: (2020)

Expressions of p53 and p21 in primary gastric lymphomas.
por: Go, J. H., et al.
Publicado: (2001)

p53-independent p21 induction by MELK inhibition
por: Matsuda, Tatsuo, et al.
Publicado: (2017)

CD151 in Respiratory Diseases
por: Wong, Amanda H., et al.
Publicado: (2020)

The inhibition of tumor protein p53 by microRNA-151a-3p induced cell proliferation, migration and invasion in nasopharyngeal carcinoma
por: Liu, Haibin, et al.
Publicado: (2019)

Retraction: The inhibition of tumor protein p53 by microrna-151a-3p induced cell proliferation, migration and invasion in nasopharyngeal carcinoma
Publicado: (2021)

Mutant p53 increases exosome-mediated transfer of miR-21-3p and miR-769-3p to promote pulmonary metastasis
por: Ju, Qiang, et al.
Publicado: (2019)

P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9
por: Tian, Xiaobing, et al.
Publicado: (2021)

Emerging Roles of the Tumor Suppressor p53 in Metabolism
por: Yu, Lili, et al.
Publicado: (2022)

The Basally Expressed p53-Mediated Homeostatic Function
por: Nagpal, Isha, et al.
Publicado: (2021)

Clinical and Immunological Effects of p53-Targeting Vaccines
por: Zhou, Shan, et al.
Publicado: (2021)

Prognostic Significance of p21 and p53 Expression in Gastric Cancer
por: Seo, Young-Ho, et al.
Publicado: (2003)

Endosome traffic machinery meets the p53–p21 axis
por: Barroso-González, Jonathan, et al.
Publicado: (2014)

p21 can be a barrier to ferroptosis independent of p53
por: Venkatesh, Divya, et al.
Publicado: (2020)

Cell cycle regulation: p53-p21-RB signaling
por: Engeland, Kurt
Publicado: (2022)

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication
por: Mansilla, Sabrina Florencia, et al.
Publicado: (2020)

Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell‐Derived Exosomes on the Senescence of Nucleus Pulposus Cells
por: Chen, Chang‐chun, et al.
Publicado: (2020)

The p53 Family: A Role in Lipid and Iron Metabolism
por: Laubach, Kyra, et al.
Publicado: (2021)

Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53
por: Zhang, Meng, et al.
Publicado: (2022)

Corrigendum: Clinical and immunological effects of p53-targeting vaccines
por: Zhou, Shan, et al.
Publicado: (2023)

The p53-p21 pathway inhibits ferroptosis during metabolic stress
por: Tarangelo, Amy, et al.
Publicado: (2018)

Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury
por: Xue, Hao, et al.
Publicado: (2023)

CDK4 inhibition diminishes p53 activation by MDM2 antagonists
por: Sriraman, Anusha, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mdupos1kl8614b9g7ejeg5u1il