Systematic In Vitro Evaluation of a Library of Approved and Pharmacologically Active Compounds for the Identification of Novel Candidate Drugs for KMT2A-Rearranged Leukemia

Patients whose leukemias harbor a rearrangement of the Mixed Lineage Leukemia (MLL/KMT2A) gene have a poor prognosis, especially when the disease strikes in infants. The poor clinical outcome linked to this aggressive disease and the detrimental treatment side-effects, particularly in children, warr...

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Detalles Bibliográficos
Autores principales: Karsa, Mawar, Ronca, Emma, Bongers, Angelika, Mariana, Anna, Moles, Ernest, Failes, Timothy W., Arndt, Greg M., Cheung, Laurence C., Kotecha, Rishi S., Kavallaris, Maria, Haber, Michelle, Norris, Murray D., Henderson, Michelle J., Xiao, Lin, Somers, Klaartje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811472/
https://www.ncbi.nlm.nih.gov/pubmed/35127484
http://dx.doi.org/10.3389/fonc.2021.779859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811472/
https://www.ncbi.nlm.nih.gov/pubmed/35127484
http://dx.doi.org/10.3389/fonc.2021.779859

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