2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity

The epigenome delineates lineage-specific transcriptional programs and restricts cell plasticity to prevent non-physiological cell fate transitions. Although cell diversification fosters tumor evolution and therapy resistance, upstream mechanisms that regulate the stability and plasticity of the can...

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Detalles Bibliográficos
Autores principales: Kusi, Meena, Zand, Maryam, Lin, Li-Ling, Chen, Meizhen, Lopez, Anthony, Lin, Chun-Lin, Wang, Chiou-Miin, Lucio, Nicholas D., Kirma, Nameer B., Ruan, Jianhua, Huang, Tim H.-M., Mitsuya, Kohzoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811753/
https://www.ncbi.nlm.nih.gov/pubmed/35021081
http://dx.doi.org/10.1016/j.celrep.2021.110220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811753/
https://www.ncbi.nlm.nih.gov/pubmed/35021081
http://dx.doi.org/10.1016/j.celrep.2021.110220

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