Discovery of Potent Glucokinase and PPARγ Dual-Target Agonists through an Innovative Scheme for Regioselective Modification of Silybin

[Image: see text] Glucokinase (GK) and PPARγ are important targets for antidiabetic use. Silybin is one of the major active ingredients of Silybum marianum. The regioselective modification of the five hydroxyl groups in the silybin structure has always been a challenge. In this study, we found that...

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Detalles Bibliográficos
Autores principales: Zhang, Zhipeng, Meng, Yanqiu, Wang, Zhan, Mei, Yu, Gao, Shite, Wu, Yuejiao, Du, Shuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811767/
https://www.ncbi.nlm.nih.gov/pubmed/35128289
http://dx.doi.org/10.1021/acsomega.1c06778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811767/
https://www.ncbi.nlm.nih.gov/pubmed/35128289
http://dx.doi.org/10.1021/acsomega.1c06778

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