DNMT1 facilitates growth of breast cancer by inducing MEG3 hyper-methylation

BACKGROUND: To understand the effect of DNMT1-mediated MEG3 promoter methylation on breast cancer progression. METHODS: Expression of DNMT1, MEG3 and miR-494-3p was assayed by qRT-PCR and western blot. Methylation-specific PCR was used to examine MEG3 promoter methylation level. ChIP, RNA binding pr...

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Detalles Bibliográficos
Autores principales: Zhu, Xiaotao, Lv, Lin, Wang, Mingzheng, Fan, Chen, Lu, Xiaofeng, Jin, Miaomiao, Li, Shuguang, Wang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812010/
https://www.ncbi.nlm.nih.gov/pubmed/35109842
http://dx.doi.org/10.1186/s12935-022-02463-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812010/
https://www.ncbi.nlm.nih.gov/pubmed/35109842
http://dx.doi.org/10.1186/s12935-022-02463-8

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