Synthesis of New 3-Arylcoumarins Bearing N-Benzyl Triazole Moiety: Dual Lipoxygenase and Butyrylcholinesterase Inhibitors With Anti-Amyloid Aggregation and Neuroprotective Properties Against Alzheimer’s Disease

A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer’s disease (AD). Most of the compounds showed weak...

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Detalles Bibliográficos
Autores principales: Pourabdi, Ladan, Küçükkılınç, Tuba Tüylü, Khoshtale, Fatemeh, Ayazgök, Beyza, Nadri, Hamid, Farokhi Alashti, Farid, Forootanfar, Hamid, Akbari, Tayebeh, Shafiei, Mohammad, Foroumadi, Alireza, Sharifzadeh, Mohammad, Shafiee Ardestani, Mehdi, Abaee, M. Saeed, Firoozpour, Loghman, Khoobi, Mehdi, Mojtahedi, Mohammad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812461/
https://www.ncbi.nlm.nih.gov/pubmed/35127652
http://dx.doi.org/10.3389/fchem.2021.810233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812461/
https://www.ncbi.nlm.nih.gov/pubmed/35127652
http://dx.doi.org/10.3389/fchem.2021.810233

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