Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form. Mutations in TREM2 have been linked to increased risk of Alzheimer’s disease (AD). A prominent neuropathological component o...

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Detalles Bibliográficos
Autores principales: Belsare, Ketaki D., Wu, Haifan, Mondal, Dibyendu, Bond, Annalise, Castillo, Erika, Jin, Jia, Jo, Hyunil, Roush, Addison E., Pilla, Kala Bharath, Sali, Andrej, Condello, Carlo, DeGrado, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812518/
https://www.ncbi.nlm.nih.gov/pubmed/35082148
http://dx.doi.org/10.1073/pnas.2114486119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812518/
https://www.ncbi.nlm.nih.gov/pubmed/35082148
http://dx.doi.org/10.1073/pnas.2114486119

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