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Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales
Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of signaling across different cellular compartments. However, how nonenzymatic PTMs—despite their direct relevance to covalent drug development—impinge on cross-compartment signaling remains inaccessible as current targe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812531/ https://www.ncbi.nlm.nih.gov/pubmed/35082156 http://dx.doi.org/10.1073/pnas.2120687119 |